With the U.S. Food and Drug Administration (FDA) formally revoking the use of FD&C Red No. 3 in food and ingested drugs — and working with industry to voluntarily phase out additional petroleum-based synthetic dyes by early 2027— food, beverage, and pharmaceutical manufacturers are under growing pressure to reformulate using naturally derived colorants. But what may sound like a cleaner-label solution brings new challenges in product stability, shelf-life, and packaging performance.
Atlas, a global provider of light and weathering testing equipment, works with manufacturers across these industries to evaluate how reformulated products perform under real-world conditions. The SUNTEST® platform, used in labs worldwide, relies on high-intensity xenon arc lamps to simulate sunlight and indoor lighting. Using SUNTEST, R&D teams can rapidly screen the light stability of colors, other ingredients, and entire formulations within days.
Furthermore, within just one week, perform ASLT (accelerated shelf-life testing) to simulate six to 12 months of product shelf-life at indoor points of sale. All testing is designed to help catch color shifts, insufficient light stability, or packaging failures before products reach the market.
A Shift from Synthetic Dyes to Natural Pigments
In food manufacturing, “food coloring” is a catch-all term, but there’s a critical difference between synthetic dyes and natural pigments.
Synthetic dyes, such as Red No. 3 and others under scrutiny, are chemically stable and fully water-soluble. Natural colorants, by contrast, are typically pigment-based—suspended rather than dissolved—and more sensitive to light, oxygen, pH, and heat.
This shift introduces new formulation risks. Natural pigments can fade, shift hue, or react with other ingredients under storage or retail conditions. A fruit beverage colored with anthocyanins, for example, may darken or separate if exposed to sunlight or heat—especially in the presence of acids like citric acid. These are the kinds of issues accelerated testing can uncover early.
Considerations for Pharmaceuticals
Pharmaceutical products face similar demands: photostability of the API, proof for sufficient protection by the packaging, strict regulatory oversight, and consistency across dosage forms. The FDA’s ban on Red No. 3 in ingested drugs takes effect January 18, 2028, requiring drug makers to validate new formulations that meet stringent stability and packaging requirements. Atlas supports these efforts with accelerated SUNTEST photostability testing in compliance with the industry guidelines of ICH Q1B.
Packaging and Performance Under Pressure
Packaging also plays a role. Many materials offer limited protection against UV or oxygen, which can degrade natural pigments. Without the right testing, even seemingly stable formulations may deteriorate in transit or on the shelf.
“Many manufacturers are already facing tight timelines,” said Oliver Rahäuser, Sr. Product Manager at Atlas. “We’ve seen this trend build globally, and it’s now accelerating in the U.S. Our goal is to give teams the technical insight they need to reformulate confidently and keep pace with change.”
Atlas, a global provider of light and weathering testing equipment, works with manufacturers across these industries to evaluate how reformulated products perform under real-world conditions. The SUNTEST® platform, used in labs worldwide, relies on high-intensity xenon arc lamps to simulate sunlight and indoor lighting. Using SUNTEST, R&D teams can rapidly screen the light stability of colors, other ingredients, and entire formulations within days.
Furthermore, within just one week, perform ASLT (accelerated shelf-life testing) to simulate six to 12 months of product shelf-life at indoor points of sale. All testing is designed to help catch color shifts, insufficient light stability, or packaging failures before products reach the market.
A Shift from Synthetic Dyes to Natural Pigments
In food manufacturing, “food coloring” is a catch-all term, but there’s a critical difference between synthetic dyes and natural pigments.
Synthetic dyes, such as Red No. 3 and others under scrutiny, are chemically stable and fully water-soluble. Natural colorants, by contrast, are typically pigment-based—suspended rather than dissolved—and more sensitive to light, oxygen, pH, and heat.
This shift introduces new formulation risks. Natural pigments can fade, shift hue, or react with other ingredients under storage or retail conditions. A fruit beverage colored with anthocyanins, for example, may darken or separate if exposed to sunlight or heat—especially in the presence of acids like citric acid. These are the kinds of issues accelerated testing can uncover early.
Considerations for Pharmaceuticals
Pharmaceutical products face similar demands: photostability of the API, proof for sufficient protection by the packaging, strict regulatory oversight, and consistency across dosage forms. The FDA’s ban on Red No. 3 in ingested drugs takes effect January 18, 2028, requiring drug makers to validate new formulations that meet stringent stability and packaging requirements. Atlas supports these efforts with accelerated SUNTEST photostability testing in compliance with the industry guidelines of ICH Q1B.
Packaging and Performance Under Pressure
Packaging also plays a role. Many materials offer limited protection against UV or oxygen, which can degrade natural pigments. Without the right testing, even seemingly stable formulations may deteriorate in transit or on the shelf.
“Many manufacturers are already facing tight timelines,” said Oliver Rahäuser, Sr. Product Manager at Atlas. “We’ve seen this trend build globally, and it’s now accelerating in the U.S. Our goal is to give teams the technical insight they need to reformulate confidently and keep pace with change.”
